1型糖尿病儿童的脑电图异常:一项前性研究
Ruken Yildirim1, Ceren Günbey2
1Department of Pediatric Endocrinology, Diyarbakır Children's Hospital, Diyarbakır, Turkiye.
Turkish journal of medical sciences
|May 30, 2024
概括
在小儿1型糖尿病 (T1DM) 患者中,EEG上的性排放与谷氨酸脱酶65自身抗体 (GAD-ab) 水平无关. 两年内没有儿童患上,这表明T1DM患者脑电图异常的风险没有增加.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 1型糖尿病 (T1DM) 是一种自身免疫性疾病.
- 葡萄糖酸脱碳酶65自身抗体 (GAD-ab) 水平升高与T1DM有关.
- 在T1DM的儿童中,电脑电图 (EEG) 上可能会出现状放电.
研究的目的:
- 为了研究新诊断的儿科T1DM患者在EEG上的型分泌.
- 为了评估型排泄和GAD-ab水平之间的相关性.
- 评估EEG发现在T1DM中预测的中期效用.
主要方法:
- 一项前性纵向研究包括105名新诊断的儿科T1DM患者.
- 脑电图在诊断后7天内进行,并由儿科神经科医生审查.
- 对临床和神经学的结果,患者被跟踪了2年.
主要成果:
- 52.4%的患者呈阳性GAD-ab;2.9%的患者在EEG上显示焦点形放电.
- 没有发现型排泄和GAD-ab水平之间的显著关系.
- 在2年的随访期间,没有患者出现发作;一个患者患有吉兰-巴雷综合征.
结论:
- 儿科T1DM患者的型出院与GAD-ab无关.
- 在T1DM中EEG异常似乎不会增加的风险.
- 吉兰-巴雷综合征可能是与儿童T1DM相关的另一个自身免疫性疾病.
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