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Updated: Jun 25, 2025

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通过高效和具有成本效益的定量蛋白质学来推进纳米材料毒理学查

Tobias Stobernack1, Nils Dommershausen1, Víctor Alcolea-Rodríguez1,2

  • 1German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Max-Dohrn-Straße 8-10, 10589, Berlin, Germany.

Small methods
|May 30, 2024
PubMed
概括

本研究介绍了一种先进的双重质量标签 (TMT) 标签协议,用于毒理学中的可重复蛋白质组分析. 具有成本效益的TMT方法提高了纳米材料在肺细胞中毒性评估的灵敏度,优于无标签量化 (LFQ).

关键词:
双重质量标签 (TMT) 是一种不良结果路径 (AOP)作用方式 (MoA)纳米材料 (NM) 是一种材料.新方法方法论 (NAMs)蛋白质组学 蛋白质组学

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