转移性细胞癌的多学科系统和局部疗法:叙述性综述
Martin Zarba1, Ryo Fujiwara2, Takeshi Yuasa2
1Department of Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Canada.
Expert review of anticancer therapy
|May 30, 2024
概括
多模式癌症治疗的最新进展为转移性细胞癌 (mRCC) 提供了新的希望. 系统性免疫瘤学组合和量身定制的局部治疗改善了mRCC患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
背景情况:
- 转移性细胞癌 (mRCC) 的治疗仍然具有挑战性.
- 多模式癌症疗法在过去十年里有了显著的进化.
研究的目的:
- 审查最近用于管理mRCC的多学科方法.
- 突出了对mRCC的全身和局部治疗的进展.
主要方法:
- 审查当前的全身疗法,包括免疫瘤学 (IO) 药物.
- 分析局部疗法,如细胞还原性切除术 (CN),转移切除术,立体辐射疗法和废除技术.
- 讨论CARMENA试验对CN实践的影响.
主要成果:
- 在一线mRCC治疗中,IO组合改善了整体存活率.
- CN不太常见,但可能有利于选定的患者.
- 以转移为导向的疗法和废除技术显示出局部控制和预后影响的前景.
结论:
- 多模式治疗对于复杂的mRCC病例至关重要.
- 现代的全身 (IO-based) 和局部疗法可以改善瘤治疗结果.
- 适当的患者选择对于优化治疗疗效至关重要.
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