监测代谢功能障碍相关的脂肪性肝病的疾病进展情况
Nabil Noureddin1,2, Nedret Copur-Dahi2, Rohit Loomba1,2
1MASLD Research Center, University of California at San Diego, La Jolla, California, USA.
Alimentary pharmacology & therapeutics
|May 30, 2024
概括
监测代谢功能障碍相关的脂肪性肝病 (MASLD) 的进展和治疗反应至关重要. 本综述探讨了MASLD和代谢功能障碍相关的脂肪肝炎 (MASH) 监测生物标志物的当前文献.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 生物标志物发现发现
- 临床试验 临床试验
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题,往往进展到严重的肝病.
- MASLD的进展可能导致肝硬化,肝衰竭和肝细胞癌,增加死亡率和医疗费用.
- 有效监测MASLD进展和治疗反应仍然是一个重大的临床挑战.
研究的目的:
- 审查有关MASLD及其高级形式的诊断和监测工具的最新文献.
- 确定当前和新兴的生物标志物,以评估MASLD的疾病进展和治疗疗效.
- 突出在MASLD管理中对验证的非侵入性测试的未满足需求.
主要方法:
- 使用相关的MeSH术语,对PubMed (开始至2023年8月) 进行全面的文献搜索.
- 包括关于MASLD,MASH,NAFLD,NASH,生物标志物和临床试验的文章.
- 根据原创性,相关性和英语出版物的选择,以广泛的审查范围.
主要成果:
- 该综述综合了来自101个参考资料的信息.
- 详细介绍不同临床环境中适用于监测MASLD进展的各种生物标志物.
- 突出了目前评估治疗反应方法的现状.
结论:
- 多种生物标志物显示出在各种护理环境中监测MASLD疾病进展的潜力.
- 进一步的研究对于验证非侵入性测试以提高临床效用至关重要.
- 开发可靠的监测工具对于管理不断增加的MASLD负担至关重要.
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