辐射对头恶性瘤嗅觉功能的影响
Sourabh Manojan1, Marina Saldanha1, Sandeep Ail2
1Department of Otorhinolaryngology, KS Hegde Medical Academy, NITTE (Deemed to be University), Mangalore, Karnataka, India.
The Annals of otology, rhinology, and laryngology
|May 30, 2024
概括
头癌的放射治疗显著损害了嗅觉功能,影响了生活质量. 虽然出现了一些恢复,但在治疗后的三个月内它是不完整的.
科学领域:
- 在瘤学瘤学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 辐射疗法 辐射疗法
背景情况:
- 嗅觉功能障碍是放射治疗经常被忽视的不良影响.
- 头部和部恶性瘤通常需要放射治疗 (RT),可能会影响感官功能.
研究的目的:
- 研究RT对头部和部恶性瘤患者的嗅觉功能的影响 (不包括鼻/鼻瘤).
- 为了将嗅觉变化与放射治疗剂量参数相关联.
主要方法:
- 一项前性观察性研究涉及34名参与者,他们接受了针对头部和部恶性瘤的RT.
- 嗅觉功能使用意大利鼻腔阻塞症状评估 (I-NOSE) 尺度和修改的I-Smell测试 (识别和值得分) 在五个时间点进行评估.
- 放射治疗剂量参数,包括接近最大剂量 (D2%) 和平均剂量 (Dmean) 到鼻腔,计算并与嗅觉功能相关联.
主要成果:
- 与RT前值相比,在RT结束时观察到嗅觉识别,嗅觉值和综合嗅觉得分的显著下降.
- 意大利鼻阻塞症状评估 (I-NOSE) 评分在RT结束时达到峰值,并在3个月的随访后恢复到基线.
- 在3个月的随访期间,嗅觉功能得到了显著但不完全的恢复.
结论:
- 放射治疗导致显著的嗅觉功能障碍和与嗅觉有关的暂时生活质量下降.
- 虽然嗅觉功能在RT后3个月内还没有完全恢复,但它不会在这个随访点对整体生活质量产生不利影响.
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