循环抗氧化剂和睡眠障碍之间的关联:NHANES 2017-2018年的综合结果
Liwei Tang1, Min Liu1,2, Jingjing Mu3
1Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518055 China. jtian@szu.edu.cn.
Food & function
|May 30, 2024
概括
高水平的循环抗氧化剂,包括胡卜素和维生素C,与睡眠障碍的风险降低有关. 这项人口规模研究强调了抗氧化剂对睡眠健康的重要性,在女性中观察到的风险更大.
科学领域:
- 营养科学 营养科学
- 睡眠医学 睡眠医学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 氧化应激与许多疾病有关,已知与睡眠障碍有双向联系.
- 循环抗氧化剂水平与睡眠障碍风险之间的人口层面的关联仍未得到充分研究.
研究的目的:
- 调查大量成年人群中循环抗氧化剂水平与睡眠障碍风险之间的联系.
- 探索特定抗氧化剂和睡眠障碍之间的暴露-反应关系.
主要方法:
- 在NHANES 2017-2018周期中利用了3062名成年人 (25-75岁) 的数据.
- 测量了血清抗氧化剂水平,并通过自我报告问卷评估了睡眠状态.
- 采用通用增量模型 (GAM),多线性,二进制物流和受限立方线 (RCS) 回归进行分析.
主要成果:
- 十种抗氧化剂在报告睡眠困难的个体中显示血清度明显降低.
- 六种抗氧化剂 (阿尔法-胡卜素,阿尔法-卜素,跨-β-胡卜素,β-卜素,蛋白/卜素和维生素C) 与较低的睡眠障碍几率有显著的相关性.
- RCS模型证实了这些抗氧化剂和睡眠障碍之间的显著负面暴露-反应关系.
结论:
- 循环中的胡卜素和维生素C水平与睡眠障碍的风险相反相关.
- 循环中较高的抗氧化剂水平与经历睡眠障碍的风险明显降低有关.
- 与低循环抗氧化剂水平相关的健康风险在女性中似乎比男性更明显.
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