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在口腔状细胞癌中CD109的表达及其临床意义

Hongyu Chen¹, Junji Xu², Rong Ge³

¹Department of stomatology, Ningbo Women and Children's Hospital, Ningbo 315012, China. mangguotiantian@126.com.

Cellular and molecular biology (Noisy-le-Grand, France)

|May 30, 2024

概括

在口腔状细胞癌 (OSCC) 中,CD109蛋白显著升高,这表明其在OSCC进展中的作用,并预测淋巴结转移和病理分级.

科学领域:

在瘤学瘤学.
口腔病理学口腔病理学

背景情况:

口腔状细胞癌 (OSCC) 是一种普遍存在的恶性瘤.
了解OSCC进展的分子标志物对于改善诊断和治疗至关重要.

研究的目的:

为了研究OSCC中CD109的表达水平.
确定OSCC中CD109的临床病理意义,包括其与病理分级和淋巴结转移的关联.

主要方法:

在OSCC中使用TIMER2.0和UALCAN数据库分析CD109mRNA水平.
在正常口腔粘膜和OSCC组织中对CD109蛋白表达的免疫组合化学分析.
对CD109表达和临床变量,如淋巴结转移和瘤分化之间的相关性分析.

主要成果:

与相邻的正常组织相比,OSCC组织中的CD109mRNA水平显著更高.
在OSCC组织中,CD109蛋白表达显著增加.
在OSCC患者中,较高的CD109表达与淋巴结转移和瘤差异化的积极相关.

结论:

在OSCC中,CD109显著过度表达.
CD109表达作为一种潜在的生物标志物用于病理分级和在OSCC中淋巴结转移的预测器.

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