希腊人群中胺剂的使用结果; 一个案例系列
Petros Fotiadis1, Eleni Tsalkitzi1, Dimos Dimellis1
1Outpatient Psychiatric Department, 424 Military Hospital of Thessaloniki, Greece.
Psychiatrike = Psychiatriki
|May 30, 2024
概括
结合口服抗抑郁药物,Esketamine鼻喷剂显示出治疗耐药抑郁症症状的显著和稳定的改善. 这种疗法耐受性良好,在希腊一小群患者中出现轻微的副作用.
科学领域:
- 神经科学和精神病学 在
- 药理学 药理学是指药理学的学科.
- 临床治疗学 临床治疗学
背景情况:
- 作为NMDA受体对抗剂的埃斯凯特胺增加了谷氨酸的释放,增强了神经营养信号传递和调节情绪的大脑区域的突触功能.
- 经批准用于治疗耐药性抑郁症 (TRD) 在成年人中,埃斯基坦胺鼻雾剂与口服抗抑郁药一起使用,尽管潜在的短期副作用如迷失方向和血压升高.
研究的目的:
- 为了评估内结合口服抗抑郁药的ESKETAMINE在5名希腊患者治疗耐药抑郁症的病例系列中的有效性.
主要方法:
- 五名TRD的希腊患者在医疗监督下接受了鼻内胺和口服抗抑郁药.
- 使用MADRS,PHQ-9,CGI和PDQ-D在基线,治疗结束和一年后跟踪评估症状严重程度.
- 使用RASS,SDS,CADSS和AE/SAE清单进行副作用监测.
主要成果:
- 所有患者在所有抑郁症评分尺度上都显示出统计学上显著的改善 (p<0.05).
- 在12个月的随访期内,症状的改善仍然存在.
- 副作用通常是轻微的和可以容忍的;只有在患有并发性人格障碍的患者中发现了显著的副作用.
结论:
- 作为口服抗抑郁药的辅助剂,鼻内胺似乎有效地稳定,长期减少TRD中的抑郁症状.
- 治疗耐受性很好,这表明即使在治疗完成后,安全性也很好.
- 需要对更大样本进行进一步的研究来证实这些发现,特别是对于患有并发症的患者.
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