改善遵守口服预暴露预防的干预措施:系统审查和网络元分析
Cristian Garcia1,2, Nadia Rehman3, Jéssyca Matos-Silva3
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. cristian.garcia@mail.utoronto.ca.
AIDS and behavior
|May 30, 2024
概括
坚持HIV暴露前预防 (PrEP) 非常重要. 结合艾滋病毒自我检测和坚持反的干预措施显著改善了坚持,多组件策略显示出最有前途的结果.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 行为科学 行为科学
背景情况:
- 暴露前预防 (PrEP) 是有效的预防艾滋病毒感染.
- 用户遵守PrEP方案对于其有效性至关重要.
- 优化坚持干预措施对于最大限度地提高PrEP的公共卫生影响至关重要.
研究的目的:
- 评估PrEP坚持干预措施与常规护理或其他干预措施的比较有效性.
- 评估旨在改善PrEP遵守性的不同组件和干预组合.
- 为设计未来的遵守策略提供基于证据的建议.
主要方法:
- 从2010年开始,对随机对照试验 (RCT) 的电子数据库进行系统搜索.
- 包括涉及艾滋病毒风险人群的随机试验,随机分配到坚持干预或对照组.
- 网络元分析被用来比较干预措施,由CINeMA评估证据确定性.
主要成果:
- 与常规护理相比,艾滋病毒自我测试与坚持反改善了坚持 (RR: 1.83).
- 多组件干预 (两个或三个组件) 比单组件干预更优越.
- 单独的艾滋病毒自我测试和单独的提醒比联合策略更不有效.
结论:
- 结合艾滋病毒自我检测与坚持反的干预措施是有效的.
- 建议采用多组件的坚持策略 (2-3组件),以实现最佳的prep坚持.
- 未来的干预措施应侧重于结合多个基于证据的组成部分,以加强遵守.
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