身体活动频率,持续时间和强度对老年白内障风险的影响:孟德尔随机化研究
Yuze Mi1,2, Qinnan Zhu1,2, Yuxiang Chen1
1National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Translational vision science & technology
|May 30, 2024
概括
定期进行中度至剧烈的体力活动可以因果性地降低患老年性白内障的风险. 这项研究没有发现反向因果关系,突出体力活动.
科学领域:
- 眼科医生 眼科 眼科
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 老年白内障是全球视力障碍的主要原因之一.
- 了解可修改的风险因素对于预防策略至关重要.
研究的目的:
- 调查各种身体活动与老年白内障风险之间的因果关系.
- 根据活动频率,持续时间和强度来区分影响.
主要方法:
- 使用双向的双样本孟德尔随机化 (MR) 方法.
- 采用逆方差加权 (IVW) 方法进行初级分析.
- 通过使用MR-Egger,MR-PRESSO和Cochran的Q来评估异质性和性.
主要成果:
- 适度体力活动 (≥10分钟/周) 显示风险降低 (OR=0.765).
- 强烈的体力活动 (≥10分钟/周) 也表明风险降低 (OR=0.691).
- 较高水平的中度至强度的体力活动显著降低了白内障风险 (OR=0.552).
结论:
- 适度至剧烈的体力活动因果性地降低了老年白内障风险.
- 从白内障到体力活动之间没有明显的反向因果关系.
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