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Updated: Jun 25, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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航海员:探索Hi-Css的时间

Eric S Davis1,2, Sarah M Parker1, Nicole E Kramer1

  • 1Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States.

Bioinformatics (Oxford, England)
|May 30, 2024
PubMed
概括

马里纳是一个新的R/生物导体工具,可以高效地处理大型Hi-C数据集,用于3D染色体结构分析. 它简化了提取,聚合和绘制基因组联系数据,帮助对基因表达和疾病的研究.

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2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)

Heteronuclear single-quantum correlation spectroscopy (HSQC) is a 2D NMR technique that reveals one-bond correlations between hydrogen and a heteronucleus. The HSQC experiment is similar to the heteronuclear correlation experiment (HETCOR) but is more sensitive. In the HSQC spectrum, the proton chemical shift is plotted on the horizontal F2 axis, while the 13C chemical shift is plotted on the vertical F1 axis. The corresponding proton and 13C spectra are also shown. The HSQC contour plot does...
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2D NMR: Overview of Heteronuclear Correlation Techniques

Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other...
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