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在不确定的甲状腺结节中,ThyGeNEXT 基因组合与扩展的 miRNA 组合ThyraMIRv2 组合使用的 ThyGeNEXT 基因组的作用:一项大型的,盲目的,现实世界的观察性研究
Tanvi Verma1, Cody Marshall1, Kossivi E Dantey1
1Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
Cancer cytopathology
|May 30, 2024
概括
多平台测试版本2 (MPTXv2) 显著提高了不确定的甲状腺结节的风险分层的准确性. 这种分子检测提高了诊断精度,有助于为患有甲状腺结节的患者做出临床决策.
科学领域:
- 内分泌学 在内分泌学.
- 分子诊断学 分子诊断
- 在瘤学瘤学.
背景情况:
- 精细针吸收活检 (FNAB) 对于诊断甲状腺结节至关重要.
- 细胞学上不确定的甲状腺结节 (ITNs) 带来了诊断挑战.
- 分子分析,包括多平台测试 (MPTX),增强ITN风险分层.
研究的目的:
- 为了评估MPTXv2的诊断准确性,用于未确定的甲状腺结节.
- 为了比较MPTXv2与MPTXv1.1.的性能.
- 评估MPTXv2在风险分层中的临床实用性.
主要方法:
- 追溯分析338名患者样本,不确定甲状腺结节的诊断.
- 应用多平台测试 (MPTXv1),包括瘤基因组和microRNA分类器.
- 对MPTXv2 (ThyraMIR®v2) 的二次分析,以增加诊断效用.
主要成果:
- MPTXv2表现出高灵敏度 (96%) 和高特异性 (99%).
- 与MPTXv1 (p=0.028) 相比,MPTXv2显示出更好的精度,曲线下面积在统计上更大.
- MPTXv2导致较少的患者被归类为中度风险患者,这表明风险分层的精细化.
结论:
- 无论是MPTXv1还是MPTXv2,都表现出强大的性能,虚假阳性率低.
- MPTXv2为不确定性甲状腺结节的风险分层提供了更高的准确性.
- 将MPTXv2纳入临床实践可以提高ITN的诊断准确性.
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