在青春期早期,颗粒物暴露和默认模式网络平衡
Clara G Zundel1, Samantha Ely1,2, Cole Brokamp3,4
1Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Brain connectivity
|May 30, 2024
概括
暴露于细颗粒物 (PM2.5) 影响儿童大脑网络的发展. 较高的PM2.5水平与功能连接的改变有关,可能会影响认知和心理健康轨迹.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 发展心理学 发展心理学
背景情况:
- 空气污染与认知和心理健康问题有关,特别是在发展中年轻人中.
- 连接空气污染,认知和心理健康的神经发育机制尚未得到充分理解.
- 由于正在进行的大脑发育,年轻人尤其容易受到伤害.
研究的目的:
- 调查细颗粒物 (PM2.5) 对静止状态功能连接 (rsFC) 的影响.
- 检查随着时间的推移,默认模式网络 (DMN) 和注意网络之间rsFC的变化.
- 了解PM2.5暴露对儿童神经发育的影响.
主要方法:
- 从青少年大脑认知发展 (ABCD) 研究中对10,072名青少年 (9-12岁) 进行了rsFC的纵向评估.
- 使用混合组合时空模型估计年度环境PM2.5度.
- 分析PM2.5暴露与rsFC变化之间的关联,使用线性混合模型,控制共变量和其他污染物.
主要成果:
- 随着时间的推移,更高的PM2.5暴露与DMN网络内部rsFC的较小增加有关.
- 在涉及DMN和注意力网络的网络间rsFC中,发现了PM2.5和时间之间的显著相互作用.
- 这些网络交互的不同方向性表明了改变的发育轨迹.
结论:
- 暴露于PM2.5与DMN和注意力网络的发展和平衡的改变有关.
- 这些变化可能会影响青春期认知和心理健康症状的发展轨迹.
- 研究结果强调了空气污染对青少年大脑功能的神经发育的影响.
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