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Updated: Jun 25, 2025

TGF-β-mediated Endothelial to Mesenchymal Transition EndMT and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing
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在非小细胞肺癌中,以EHMT2为媒介的转录重编程驱动神经内分泌转化

Cheng Yang1,2, Shuxiang Ma3, Jie Zhang1,2

  • 1Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.

Proceedings of the National Academy of Sciences of the United States of America
|May 30, 2024
PubMed
概括

小细胞肺癌 (SCLC) 的转变驱动了对表皮生长因子受体氨酸激酶抑制剂 (TKI) 的耐药性. 抑制EHMT2恢复了TKI的敏感性,为克服肺腺癌中的erlotinib耐药性提供了一种治疗策略.

关键词:
在EHMT2中使用.通过WNT/β-catenin通路进行.神经内分泌转换的神经内分泌转换不是小细胞肺癌的肺癌小细胞肺癌是一种小细胞肺癌.

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