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相关概念视频

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Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Bridging the Bio-Electronic Interface with Biofabrication
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用于控制炎症的活性生物集成生物电子

Jiuyun Shi1, Saehyun Kim1, Pengju Li2

  • 1Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.

Science (New York, N.Y.)
|May 30, 2024
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概括

这项研究介绍了无生物电子接口的活跃生物集成生活电子 (ABLE) 平台. 该平台可以同时监测生物原生,生物机械和生物电特性以诊断疾病.

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科学领域:

  • 生物医学工程
  • 生物电子
  • 微生物学

背景情况:

  • 合成材料和活体组织之间的差异挑战生物电信号传导.
  • 开发电子设备和生物组织的无接口对于疾病诊断和治疗至关重要.

研究的目的:

  • 引入活跃的生物集成生活电子 (ABLE) 平台.
  • 在微生物-哺乳动物界面实现多模式信号传输.
  • 为了监测皮的微生物驱动干预.

主要方法:

  • 使用生物电子布局和 Staphylococcus epidermidis-laden 水凝复合物开发了一个生物接口.
  • 使用热释放的氨酸聚合物链来维持细菌活性的准备的粘弹性水凝.
  • 使用电生理记录和无线探测来监测皮肤电阻,体温和湿度.

主要成果:

  • 在ABLE平台上展示了生物原生,生物机械和生物电特性的能力.
  • 活体水凝复合物支持高细菌活力.
  • 通过各种生理参数,ABLE成功监测了银病的微生物驱动干预.

结论:

  • 提供无生物电子接口的新方法.
  • 这种生物界面促进了微生物与哺乳动物之间的多模式信号传输.
  • ABLE显示了微生物驱动疾病如牛皮的实时监测潜力.