限制电子尼古丁输送系统 (ENDS) 尼古丁剂量,通过控制尼古丁流量在有限的吸气持续时间
Alison J Patev1, Madison Combs1, Nicoleta Gaitan1
1Department of Psychology, Center for the Study of Tobacco Products, College of Humanities and Sciences, Virginia Commonwealth University.
电子尼古丁输送系统 (ENDS) 控制尼古丁流量和吸气持续时间,控制尼古丁剂量. 更高的尼古丁流量增加了血尼古丁和心率,同时减少了渴望.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 行为科学 行为科学
- 公共卫生 公共卫生
背景情况:
- 尼古丁流量,电子尼古丁输送系统 (ENDS) 的尼古丁排放速度,是评估其滥用潜力的关键因素.
- 吸入的尼古丁剂量由尼古丁流量和用户吸气持续时间决定,需要对这两种参数进行控制以有效调节.
研究的目的:
- 为了研究不同ENDS尼古丁流量对生理和主观反应的影响,当吸气持续时间标准化时.
- 为了确定是否操纵尼古丁流量,以及固定的吸气持续时间,可以有效控制尼古丁剂量并影响用户体验.
主要方法:
- 32名参与者完成了四次实验,每次都具有不同的尼古丁流量水平 (没有,低,类似香烟,高).
- 设备的功率保持不变,而液体尼古丁度调整以操纵尼古丁流量.
- 在每次会议期间,参与者参与了两次ENDS使用,时间严格限制为2秒,测量了血尼古丁,心率和主观效应.
主要成果:
- 更高的尼古丁流量水平导致血尼古丁度显著增加和心率升高.
- 增加的尼古丁流量导致自我报告的渴望和使用尼古丁的冲动减少.
- 参与者报告说,在更高的尼古丁流量条件下,增强了积极的主观效应,例如平静.
结论:
- 操纵尼古丁流量,特别是当与有限的吸气持续时间相结合时,提供了一种可行的方法来控制ENDS中的尼古丁剂量.
- 调查结果强调,在ENDS的监管策略中,针对尼古丁流量和吸气持续时间至关重要.
- 这种有针对性的监管可能会减少滥用责任,同时可能有助于吸烟者从传统香烟过渡到ENDS.
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