慢性心力衰竭患者中拉米普利的群体药理动力学:现实世界的纵向研究
Katja Čvan Trobec1, Iztok Grabnar1, Jurij Trontelj1
11University of Ljubljana Faculty of Pharmacy 1000 Ljubljana, Slovenia.
Acta pharmaceutica (Zagreb, Croatia)
|May 30, 2024
概括
身体组成会影响慢性心力衰竭 (CHF) 患者的拉米普利尔的药理动力学. 拉米普利和拉米普利酸的药理动力学随着时间的推移保持稳定,支持定期监测.
科学领域:
- 药理学 药理学是指药理学的学科.
- 心脏病学 心脏病学
- 临床药房 临床药房
背景情况:
- 像拉米普利尔这样的 ангиотензин转化酶抑制剂对于治疗慢性心力衰竭 (CHF) 至关重要.
- 了解拉米普利的药理动力学,特别是它与人体组成的相互作用,对于优化CHF患者的治疗至关重要.
- 之前的研究还没有完全阐明人体成分对拉米普利和拉米普利酸药理学随时间推移的影响.
研究的目的:
- 为了研究身体成分如何影响拉米普利尔及其活性代谢物拉米普利酸的药理动力学.
- 在CHF患者长期接受拉米普利治疗后,评估这些药物动力学概况的任何变化.
主要方法:
- 使用非线性混合效应母代谢物模型来评估药理动力学.
- 最初研究了23名接受拉米普利治疗的CHF患者,其中19名在平均8个月后返回进行随访.
- 身体组成参数与拉米普利尔和拉米普利拉特清除率相关.
主要成果:
- 没有脂肪的质量,用一种全度关系来描述,最好地解释了身体大小和组成对药理动学的影响.
- 拉米普里尔清除与患者年龄和拉米普里尔剂量有关.
- 拉米普利拉清除受膜过率和拉米普利尔剂量的影响.
- 在研究访问之间,没有观察到拉米普利尔或拉米普利拉特药理动学的临床显著变化.
结论:
- 身体组成,特别是无脂肪质量,在心血管疾病患者的拉米普利尔和拉米普利的药理动力学中起作用.
- 在这个人群中,拉米普利的药理动力学在8个月的时间内相对稳定.
- 定期进行6个月的门诊访问可能足以监测拉米普里尔治疗的有效性和安全性.
更多相关视频
07:49Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
Published on: July 21, 2023
1.3K
07:38Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
Published on: January 20, 2023
3.5K
相关概念视频
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
421
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
421
01:11Renal Failure: Dose Adjustments
84
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
84
01:22Heart Failure Drugs: Diuretics
363
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
363
01:22Heart Failure Drugs: β-Blockers
336
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
336
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
57
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
57