在患有状细胞相关中风或疑似神经疾病的成年人认知功能障碍的决定因素
Despina Messimeris1,2, Hugo Bismuth2, Corentin Provost1,3
1Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Paris, France.
Blood advances
|May 30, 2024
概括
认知功能障碍在患有状细胞疾病 (SCD) 的成年人中很常见,影响处理速度,短期记忆和工作记忆. 这些缺陷与心脏病发作和血管病变等脑损伤有关,突出显示了SCD的神经影响.
科学领域:
- 神经学 神经学
- 血液学 血液学 血液学
- 神经心理学 神经心理学
背景情况:
- 状细胞疾病 (SCD) 由于器官损伤,特别是大脑,严重影响成人预后.
- 认知功能障碍是成年SCD患者常见但经常被研究不足的慢性神经问题.
- 现有的关于成人SCD认知障碍的研究主要是描述性的,缺乏详细的描述.
研究的目的:
- 为了全面描述成年SCD患者的认知概况.
- 研究特定认知缺陷与大脑异常之间的关联.
- 确定可能导致SCD认知功能障碍的潜在风险因素.
主要方法:
- 一组96名成年SCD患者接受了神经学评估.
- 进行神经心理测试以评估认知功能.
- 大脑磁共振成像/血管造影和多普勒超声波用于评估脑血管异常.
主要成果:
- 在处理速度 (58%),短期记忆 (34%) 和工作记忆 (24%) 中观察到认知缺陷.
- 大脑中风 (56%) 和内血管病变 (49%) 是普遍存在的;20%没有脑部异常.
- 处理速度和短期记忆缺陷与区域性心脏病发作相关;与血管病变和较低教育相关的工作记忆缺陷.
结论:
- 认知功能障碍是成人SCD的一个显著表现,特别是在那些中风或疑似神经问题的人中.
- 特定的认知缺陷与不同的大脑病变和人口统计因素 (如教育水平) 有关.
- 评估认知功能对于监测SCD进展以及在临床试验和纵向研究中使用至关重要.
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