探索双醇和酸盐暴露水平与前列腺癌发生率之间的关系
Xuan Wang1, Zifan Hu1, Yuming Jin2
1Department of Public Health Laboratory Science, West China School of Public Health and West China Fourth Hospital, West China-PUMC C.C. Chen Institute of Health, Sichuan University, Chengdu 610041, China.
尿液中高水平的双甲 (BPA) 和二甲基酸 (DEHP) 与前列腺癌 (PCa) 风险增加有关. 这项研究开发了一种UPLC-MS/MS方法来分析这些化学物质暴露及其与PCa的关联.
科学领域:
- 环境健康 环境健康
- 分析化学 分析化学
- 在瘤学瘤学.
背景情况:
- 双和酸盐是常见的环境化学物质,具有潜在的内分泌干扰特性.
- 前列腺癌 (PCa) 是一个重要的公共卫生问题,环境因素可能在它的发展中发挥作用.
研究的目的:
- 开发和验证一种超高性能液体色谱-并联质谱法 (UPLC-MS/MS) 方法,用于同时分析尿液中的双和甲酸盐代谢物.
- 调查尿路双醇和甲酸代谢物水平与前列腺癌风险之间的关联.
主要方法:
- 用固相提取 (SPE) 净化尿液样本,并使用UPLC-MS/MS.分析18种代谢物.
- 进行了一项病例控制研究,涉及187个PCa病例和151个对照.
- 使用后勤回归分析来评估代谢物水平与PCa风险之间的关联.
主要成果:
- 该UPLC-MS/MS方法证明了对代谢物分析的高灵敏度和精度.
- 在几乎所有样本中检测到双甲 (BPA) 和大多数甲酸盐代谢物.
- 高水平的BPA和二2-乙烯基甲酸盐 (DEHP) 与前列腺癌的风险增加有显著关联.
结论:
- 开发的UPLC-MS/MS方法对于评估对双和酸盐的暴露是有效的.
- 暴露于BPA和DEHP可能是前列腺癌发展的危险因素.
- 需要进一步的研究来阐明这些关联背后的机制.
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