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大麻戒断对多发性硬化症患者的认知和休息状态网络活动的影响:一项初步研究

Cecilia Meza¹, Cristiana Stefan², W Richard Staines³

¹Sunnybrook Research Institute, Division of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

NeuroImage. Clinical

|May 30, 2024

概括

在患有多发性硬化症 (pwMS) 的人群中,禁用大麻28天导致了更好的默认模式网络 (DMN) 激活和增强认知功能. 这表明大麻戒断可以积极影响pwMS中的大脑功能和认知.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
神经学神经学

背景情况:

以前的研究表明,在患有多发性硬化症 (pwMS) 的人中长期使用大麻可能会导致认知能力改善,而禁欲诱导的大脑激活变化.
默认模式网络 (DMN) 对认知功能至关重要,其在 pwMS 中通过大麻使用的调制需要进一步调查.

研究的目的:

调查28天大麻戒断对认知障碍患者DMN激活模式的影响,频繁使用大麻的 pwMS.
为了将DMN活动的变化与大麻戒断期后的认知改善相关联.

主要方法:

33名认知障碍的 pwMS,经常使用大麻的人,接受了基线神经心理评估和休息状态功能性MRI (rs-fMRI).
参与者被随机分配到大麻继续 (CC) 或大麻戒断 (CW) 组,持续28天,并对尿液进行遵守监测.
用独立组件分析 (ICA) 和双回归分析了rs-fMRI数据,以比较群体之间的和群体内的DMN活性.

主要成果:

在CC和CW组之间没有观察到DMN活性的显著基线差异.
经过28天,CW组显示在左后带带状和右角环状中DMN激活显著增加,与CC组相比.
CW组在多个领域表现出显著的认知改善,并增加了左海马和右中间前额叶皮层的激活.

结论:

在pwMS中禁用大麻28天与DMN活动模式的逆转有关.
这些DMN变化与认知功能的显著改善相关,突显了大麻戒断在这个人群中的潜在治疗益处.

关键词:

大麻大麻大麻大麻大麻大麻大麻认知障碍认知障碍是一种认知障碍.多发性硬化症是多发性硬化症.休息状态休息状态

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