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Updated: Jun 25, 2025

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针对A型流感NS1和TRIM25之间的接口的植物化合物的分子查,以增强宿主免疫反应

Muhammad Suleman1, Abrar Mohammad Sayaf2, Abbas Khan3

  • 1Laboratory of Animal Research Center (LARC), Qatar University, Doha, Qatar; Center for Biotechnology and Microbiology, University of Swat, Swat, Pakistan.

Journal of infection and public health
|May 30, 2024
PubMed
概括

研究人员确定了天然化合物,可以抑制A型流感病毒NS1蛋白与TRIM25结合,这是病毒免疫逃避的关键步骤. 这些化合物由于它们强烈的结合亲和力和有利的类似药物的特性,显示出它们作为新的抗病毒剂的前景.

关键词:
主体免疫力 主体免疫力流感A NS1 流感A NS1 流感分子动力学分子动力学自然产品数据库 自然产品数据库在 TRIM2525 中,

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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