阿特拉津的内分泌毒性及其潜在机制
Haotang Zhao1, Honghao Qian1, Jianwei Cui1
1Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
Toxicology
|May 30, 2024
概括
一种常见的除草剂阿特拉辛 (ATR) 通过影响激素生产,DNA,神经递质和新陈代谢来破坏内分泌系统. 天然产品可能有助于减轻其毒性影响,尽管需要更多的人体研究.
科学领域:
- 环境毒理学环境毒理学
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 阿特拉 (ATR) 是一种广泛使用的除草剂,具有很长的环境半衰期.
- 暴露是通过摄入,饮用水和皮肤接触发生的,作为内分泌干扰物的风险.
- 众所周知,ATR会对生殖,神经,上腺和甲状腺系统产生负面影响.
研究的目的:
- 综合审查阿特拉对内分泌系统的有害影响.
- 要总结ATR内分泌干扰背后的分子机制.
- 编制可以减轻ATR毒性影响的天然产品.
主要方法:
- 对Atrazine对内分泌干扰作用的现有研究的文献综述.
- 分析分子机制,包括基因表达,DNA合成和神经递质通路.
- 收集有关自然产品干预措施的数据.
主要成果:
- ATR 影响下丘脑-垂体-淋巴结核 (HPG) 轴,影响类固醇生成.
- 它通过破坏DNA合成和甲基化而导致生殖和发育毒性.
- 通过改变多巴胺通路和其他神经递质,ATR诱导神经毒性.
- 它破坏了新陈代谢,降低了基础代谢率,损害了氧化酸化,并导致胰岛素抵抗.
- 像黑素,黄素和维生素这样的天然产品显示出减轻ATR毒性的潜力.
结论:
- 阿特拉通过多个分子通路对内分泌系统构成重大风险.
- 需要进一步的研究,特别是基于人口的研究,才能充分了解人类健康的影响.
- 自然化合物为管理阿特拉辛诱导的毒性提供了潜在的途径.
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