肠道微生物群的组成与精神疾病的功能领域的变化有关
Danique Mulder1, Babette Jakobi2, Yingjie Shi2
1Department of Psychiatry, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
Brain, behavior, and immunity
|May 30, 2024
概括
肠道微生物群的组成与精神疾病中的特定大脑功能领域有关. 这些发现表明,个性化的肠道微生物干预措施有可能改善心理健康结果.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 在精神疾病中注意到微生物组成的变化,但症状特异性尚不清楚.
- 肠道微生物群在心理健康中的作用,特别是在与压力相关的和神经发育条件下,需要进一步研究.
研究的目的:
- 调查肠道微生物群组成和研究领域标准 (RDoC) 功能领域之间的关联.
- 在有或没有精神病并发症的个体中探索这些联系,重点关注压力和神经发育障碍.
主要方法:
- 分析了369名参与者的肠道微生物群 (272名精神病诊断者,97名对照者).
- 使用主要组件分析 (PCA) 估计的RDoC域.
- 通过多重线性回归和PERMANOVA评估微生物群域关联,调整共变量.
主要成果:
- 确定了四个RDoC领域:负价值,社会过程,认知系统和兴奋/调节系统.
- 发现了这些域与八个微生物属 (例如,Sellimonas,Oscillibacter,Ruminococcus torques) 之间存在显著的关联.
- 与负价值,社会过程,认知系统和兴奋/调节功能相关的特定属 (所有FDR<0.05).
结论:
- 肠道微生物群的组成与精神病患者和健康个体的功能领域有关.
- 这些发现表明潜在的免疫介导途径和针对微生物群的干预措施的开放可能性.
- 需要进一步的研究来确认因果关系并了解潜在的机制.
相关概念视频
Anatomy of the Intestines
71.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.8K
Irritable Bowel Syndrome I: Introduction
268
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
268
Bacterial Flora of the Large Intestine
421
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
421
Depression: Overview
238
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
238
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
575
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
575
Chronic Bowel Disorders: Introduction
440
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
440


