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Updated: Jun 25, 2025

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能否通过溶性-扩散模型预测zwitterionic化合物的膜透性?

Andrea Ebert1, Carolin Dahley1

  • 1Department of Computational Biology & Chemistry, Helmholtz Centre for Environmental Research (UFZ), Permoserstraße 15, 04318 Leipzig, Germany.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
|May 30, 2024
PubMed
概括

中性形式,而不是zwitterionic形式,决定了zwitterionic化合物的膜透性. 这一发现简化了使用溶解度-扩散模型的药物透率的in silico预测.

关键词:
在Caco-2中使用.内部膜的透性 内部膜的透性这就是MDCKK的MDCK.被动透性是一种被动的透性.可溶性-扩散模型的可溶性-扩散模型.这里是Zwitterions的位置.

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