将过氧化添加到赫西丁糖酸盐中是否会提高皮肤制剂在降低皮肤Cutibacterium水平方面的有效性? 一个随机对照试验
William L Crutcher1, Joshua C Acidera1, Anastasia J Whitson1
1Department of Orthopedics and Sports Medicine, Investigation Performed at the University of Washington, Seattle, WA, USA.
Journal of shoulder and elbow surgery
|May 30, 2024
概括
将过氧化 (H2O2) 添加到素酸盐 (CHG) 中并没有改善皮肤准备减少Cutibacterium细菌. 单独的CHG和H2O2加CHG都没有有效地消除从脂质腺重新繁殖的细菌.
科学领域:
- 手术部位感染的预防和预防.
- 微生物学 微生物学
- 皮肤病学 皮肤病学
背景情况:
- 肩围假肢关节感染经常是由Cutibacterium引起的.
- 菌存在于皮肤的脂质腺体中,使皮肤的准备具有挑战性.
- 关于过氧化 (H2O2) 作为氧化 (CHG) 的辅助剂,用于减少Cutibacterium的有效性,证据是相互矛盾的.
研究的目的:
- 为了评估添加H2O2到CHG在降低皮肤Cutibacterium水平方面的有效性.
- 为了比较H2O2+CHG与仅含CHG的皮肤制剂的疗效.
- 为了评估Cutibacterium在准备后的皮肤表面的重新填充.
主要方法:
- 这是一项随机对照研究,涉及18名男性志愿者 (36个肩膀).
- 肩膀被随机分配,接受单纯CHG或H2O2+CHG制剂.
- 在准备Cutibacterium培养之前和60分钟后收集皮肤拭子.
主要成果:
- 在预先准备时,100%的肩膀显示出Cutibacterium.
- 在60分钟内,Cutibacterium重组发生在CHG单一和H2O2+CHG组 (P=1.00) 的78%中.
- 这两种制剂都显著降低了Cutibacterium水平,但在60分钟内仍然存在大量水平.
结论:
- 将H2O2添加到CHG并没有在减少皮肤Cutibacterium方面提供任何额外的好处.
- 只有CHG或H2O2+CHG的制剂都没有消除Cutibacterium从脂质腺体的重新繁殖.
- 可能需要进一步的策略来解决手术现场准备中的Cutibacterium殖民问题.
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