牙周病和中风风险的标志物:INTERSTROKE病例控制研究
Robert P Murphy1, Graeme J Hankey2, Conor Judge3
1HRB Clinical Research Facility Galway, School of Medicine, University of Galway, Galway, Ireland; Department of Neurology, Sunnybrook Health Sciences, University of Toronto, Canada.
概括
严重的牙周病,如牙脱落等症状,是中风的重要危险因素. 解决牙健康问题可能有助于降低全球中风风险.
科学领域:
- 心血管健康 心血管健康
- 口腔卫生流行病学 口腔卫生流行病学
- 全球公共卫生 全球公共卫生
背景情况:
- 牙周病越来越多地被认为是脑血管事件的潜在可修改风险因素.
- 了解口腔健康对中风发病率的全球影响对于公共卫生倡议至关重要.
研究的目的:
- 在全球范围内量化牙周病标志物与中风风险之间的关联.
- 为了研究这种跨多种人群和不同类型的中风亚型之间的关系.
主要方法:
- 利用了INTERSTROKE研究的数据,这是一项关于第一次急性中风的大型国际病例控制调查.
- 评估牙周病使用关于过去一年内疼痛的牙,疼痛的牙和失去牙的标准化问题.
- 采用多变量条件逻辑回归来分析牙周病标志物与急性中风之间的联系.
主要成果:
- 在失去牙和增加中风风险之间发现了显著的关联 (OR 1.11,95% CI 1.01-1.22).
- 对于单独疼痛的牙或牙没有观察到任何显著的关联.
- 当出现多个牙周病症状时,人们注意到中风的几率逐渐增加,这三种症状的几率最高 (OR 1.34,95% CI 1.00-1.79).
结论:
- 研究结果表明,严重的牙周病是急性中风的危险因素.
- 牙周病是中风预防策略的潜在可修改的目标.
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