在HER-2阴性乳腺癌中导航PI3K/AKT通路的复杂性:生物标志物及其他方面

M Sirico1, F Jacobs2, C Molinelli3

  • 1Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.

概括

新的PI3K/AKT抑制剂对转移性乳腺癌具有特定基因变异的治疗有希望. 像PIK3CA突变这样的生物标志物是关键的,但最佳的患者选择和抵抗机制需要进一步研究.

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