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来自Artocarpus communis的抗病毒C-基拉尼化黄

Rui-Li Huang¹, Wei Tang², Chaoqun Wang¹

¹State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, People's Republic of China; Center for Bioactive Natural Molecules and Innovative Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China.

|May 30, 2024

概括

研究人员从Artocarpus communis的叶子中分离出了十种C-基拉尼化黄. 一些化合物表现出对呼吸道同胞性病毒和简单疹病毒1型病毒的抑制活性.

科学领域:

自然产品化学自然产品化学
有机化学有机化学
药用化学医学化学

背景情况:

阿托卡普斯 (Artocarpus communis) 是一种生物活性化合物的植物来源.
基化黄类化合物是具有多样性结构的独特类自然产品.
自然产品中的新型异环基基架具有显著的兴趣.

研究的目的:

从Artocarpus communis的叶子中分离和表征C-基拉尼化黄.
为了阐明新型C-geranylated flavonoids的化学结构.
调查分离化合物的潜在抗病毒活性.

主要方法:

使用色谱技术分离化合物.
通过综合光谱分析 (NMR,MS) 阐明结构.
单晶X射线衍射和量子化学电子循环二元化计算用于结构确认.

主要成果:

隔离了十种C-geranylated黄和三种已知的类似物.
确定了9种新的化合物,即阿托卡龙A-I,具有不寻常的异环基架.
阿托卡龙E和G-I具有一个新的6H-[c]核.
阿尔托卡龙J是第一个报告的C-geranylated aurone,具有C-9-C-16链接.
化合物1,2,4,8,11和12在体外表现出对呼吸道同胞性病毒和简单疹病毒1型病毒的抑制活性.

结论:

这项研究描述了来自Artocarpus communis的新型C-geranylated flavonoid,包括独特的异环结构.
这些发现扩大了C-geranylated黄素的结构多样性.
隔离的化合物显示出开发为抗病毒剂的潜力.

关键词:

抗病毒活性具有抗病毒活性.这种植物是Artocarpus communis.在C-geranylated的黄类化合物中.摩拉属植物摩拉属植物结构阐明结构阐明

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