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肠道脂肪酸结合蛋白作为复杂的内血管大动脉手术后胃肠道并发症的潜在生物标志物

Isabelle Grafver¹, Måns Edström², Jenny Seilitz³

¹Faculty of Medicine and Health, Department of Cardiothoracic and Vascular Surgery, Örebro University, Örebro University Hospital, Örebro, Sweden; School of Medical Sciences, Örebro University, Örebro, Sweden.

Annals of vascular surgery

|May 30, 2024

概括

肠道脂肪酸结合蛋白 (I-FABP) 水平升高和急性胃肠道损伤 (AGI) 等级在手术后显示,复杂的大动脉动脉瘤患者的胃肠道并发症风险较高. 这些标志物可能有助于术后管理.

科学领域:

血管外科血管外科
胃肠病学胃肠病学
生物标志物研究生物标志物研究

背景情况:

复杂动脉瘤的内血管大动脉动脉瘤修复 (EVAR) 携带胃肠道 (GI) 并发症的风险.
肠道脂肪酸结合蛋白 (I-FABP) 是肠道损伤的潜在生物标志物.

研究的目的:

为了研究I-FABP,急性胃肠道损伤 (AGI) 等级和复杂动脉瘤的EVAR后的胃肠道并发症之间的关联.

主要方法:

17名因复杂动脉瘤接受EVAR治疗的患者被纳入.
血I-FABP水平使用ELISA测量.
每天使用AGI等级评估消化道功能.

主要成果:

术后较高的I-FABP度与较高的AGI等级相关.
患有胃肠道并发症的患者具有更高的AGI等级和I-FABP水平.
消化道功能障碍 (AGI等级≥2) 与并发症增加和更长的ICU停留有关.

结论:

手术后的I-FABP和AGI等级与EVAR患者的胃肠道并发症有关.
这些标记可能对术后管理和风险分层有价值.

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