拯救性射频除,随后是外辐射疗法,用于不可手术的复发性分化甲状腺癌
Chung-Shih Chen1, Sheng-Dean Luo2,3, Yen-Hsiang Chang4
1Department of Radiation Oncology & Proton and Radiation Therapy Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
概括
射频剥离 (RFA) 与外部束辐射疗法 (EBRT) 结合,为侵袭关键器官的重复差异化甲状腺癌 (rDTC) 提供安全有效的治疗方法,实现高生存率和局部区域控制率.
科学领域:
- 在瘤学瘤学.
- 干预性放射学 干预性放射学
- 辐射瘤学 辐射瘤学
背景情况:
- 具有关键器官入侵的重复差异化甲状腺癌 (rDTC) 存在重大治疗挑战.
- 射频剥离 (RFA) 和外部束辐射疗法 (EBRT) 的结合是管理这种病例的一个有前途的方法.
研究的目的:
- 评估RFA的安全性和有效性,然后在患有不可手术的残留或复发差异化甲状腺癌 (rDTC) 的患者中进行EBRT.
主要方法:
- 在2020年4月至2022年1月期间,对11名患有14个rDTC病变的患者进行了以RFA和EBRT治疗的回顾性研究.
- 在成像指导下,RFA使用了一种自由手的"移动拍摄"技术.
- 对于侵袭关键结构的病变,进行了有限场EBRT (66 Gy分33小部分).
主要成果:
- 所有患者都实现了局部区域控制,随访时间中位数为33.7个月.
- 两年生存率为90.9%,平均体积减少率为92.1%.
- 与治疗相关的毒性通常是轻微的,包括暂时的声,辐射皮肤炎和消化不良,没有3级或更高的并发症.
结论:
- 挽救RFA之后EBRT是一个可行的,有效和安全的治疗选择,用于患有复发分化甲状腺癌的患者.
- 这种综合模式的方法表明,在处理具有器官侵袭的具有挑战性的rDTC病例方面,有很大的潜力.
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