可调节和快速固化的氨酸水凝灵感来源于catechol架构,用于增强粘附性质
Fan Yang1, Yunlu Chen2, Wentao Zhang1
1Center for Plastic & Reconstructive Surgery, Department of Stomatology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, PR China.
International journal of biological macromolecules
|May 30, 2024
概括
研究人员使用蓝光固化技术开发了用甲基醇修饰的氨酸 (HA) 水凝. 这些先进的HA水凝为生物医学应用提供了更好的机械强度和快速原型.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 生物医学工程 生物医学工程
背景情况:
- 氨酸 (HA) 水凝具有出色的生物相容性和生物降解性,使其适用于各种医疗用途.
- 然而,纯的HA水凝具有有限的机械强度和较差的粘粘性,限制了它们在伤口包裹和3D打印等领域的应用.
- 开发具有增强性能的修改HA水凝对于扩大其生物医学潜力至关重要.
研究的目的:
- 合成和表征在现场形成的甲基醇修饰的HA水凝.
- 为了研究不同类甲醇含量对水凝物理化学性质的影响.
- 评估水凝适用于快速原型和生物医学应用,包括3D打印.
主要方法:
- 用不同度的甲基醇 (0-40%) 修改过的氨酸水凝的合成.
- 使用蓝光固化反应对水凝进行交叉连接.
- 评估水凝的性能,包括机械强度,湿粘度和生物相容性.
- 使用DLP3D打印与优化的水凝前体作为生物墨水制造微观结构.
主要成果:
- 甲基醇修饰显著改善了HA水凝的机械性能.
- 合成的水凝表现出快速原型制造能力,优异的湿粘性和良好的生物相容性.
- 一个模仿人类肝叶片的微结构成功地使用DLP3D打印与catechol修饰的HA生物墨水成功制造出来.
- 实现了可调整的物理化学特性和高效的蓝光固化.
结论:
- 与纯的HA水凝相比,Catechol修饰的HA水凝提供了增强的机械性能和快速原型的能力.
- 这些先进的水凝显示出作为生物墨水的巨大潜力,用于3D打印复杂的生物结构.
- 开发的材料显示出对各种生物医学工程应用的前景,包括组织工程和再生医学.
相关概念视频
02:45Acid-Catalyzed Hydration of Alkenes
Alkenes react with water in the presence of an acid to form an alcohol. In the absence of acid, hydration of alkenes does not occur at a significant rate, and the acid is not consumed in the reaction. Therefore, alkene hydration is an acid-catalyzed reaction.
02:34Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration
The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.
01:28Structures of Carboxylic Acid Derivatives
Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
01:13Esters to Carboxylic Acids: Acid-Catalyzed Hydrolysis
Hydrolysis of esters under acidic conditions proceeds through a nucleophilic acyl substitution. In the presence of excess water, the reaction proceeds in a reversible manner, forming carboxylic acids and alcohols.
During hydrolysis, the ester is first activated towards nucleophilic attack through the protonation of the carboxyl oxygen atom by the acid catalyst. The protonation makes the ester carbonyl carbon more electrophilic. In the next step, water acts as a nucleophile and adds to the...
During hydrolysis, the ester is first activated towards nucleophilic attack through the protonation of the carboxyl oxygen atom by the acid catalyst. The protonation makes the ester carbonyl carbon more electrophilic. In the next step, water acts as a nucleophile and adds to the...
01:26Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism
The Hofmann and Curtius rearrangement reactions can be applied to synthesize primary amines from carboxylic acid derivatives such as amides and acyl azides. In the Hofmann rearrangement, a primary amide undergoes deprotonation in the presence of a base, followed by halogenation to generate an N-haloamide. A second proton abstraction produces a stabilized anionic species, which rearranges to an isocyanate intermediate via an alkyl group migration from the carbonyl carbon to the neighboring...
01:20Anionic Chain-Growth Polymerization: Overview
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...