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Updated: Apr 10, 2026

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快速的P-TEFb依赖的转录重组支持质瘤对放射治疗的适应性反应

Faye M Walker1, Lays Martin Sobral1, Etienne Danis2,3

  • 1Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.

Nature communications
|May 30, 2024
PubMed
概括

在儿科高度质瘤中,抑制P-TEFb与放射治疗一起增强了癌细胞死亡. 这种方法针对必不可少的适应性计划,提高这些侵袭性脑瘤的治疗疗效.

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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