三胞胎神经疼痛 三胞胎神经疼痛
Sait Ashina1,2,3, Carrie E Robertson4, Anan Srikiatkhachorn5
1BIDMC Comprehensive Headache Center, Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA. sashina@bidmc.harvard.edu.
Nature reviews. Disease primers
|May 30, 2024
概括
三神经疼痛 (TN) 是一种严重的面部疼痛状况. 治疗包括像卡巴马西平这样的药物,以及作为持续疼痛的选择的手术.
科学领域:
- 神经学 神经学
- 疼痛医学 医学 疼痛医学
背景情况:
- 三神经疼痛 (TN) 是一种使人虚弱的面部疼痛障碍.
- 它提出了诊断和治疗的挑战,影响了生活质量.
- TN亚型包括古典性,二次性和特异性,女性和老年人患病率更高.
研究的目的:
- 为了提供关于三角神经疼痛的全面概述.
- 讨论其流行病学,病理生理学和诊断方面的考虑.
- 概述当前的治疗策略,包括药物治疗和手术选择.
主要方法:
- 对TN发病率和流行率的流行病学数据的审查.
- 对多因素病理生理学的分析,包括神经血管压缩和脱髓化.
- 对参与疼痛调节的大脑区域的神经成像发现的检查.
- 评估治疗方法,从一线药物到外科手术.
主要成果:
- TN病理生理学涉及遗传,解剖学和神经生理学因素,导致神经元过度兴奋.
- 神经血管压缩和三角形 afferents 的脱髓化是关键的病因因素.
- 大脑成像显示疼痛调节和情绪处理区域的异常.
- 药物治疗 (碳胺,氧胺) 是最初的治疗方法,而手术作为另一种选择.
结论:
- 跨国网络管理需要个性化,多方面的方法.
- 当药物治疗失败或禁用时,早期考虑手术选择至关重要.
- 了解TN的复杂机制对于有效的治疗策略至关重要.
相关概念视频
Cranial Nerves: Types Part I
2.5K
Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves, with the first six being essential in sensory perception, motor control, and autonomic functions related to the head and neck.
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...
2.5K
Cranial Nerves: Types Part II
2.4K
Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves. While the first six innervate the head and neck, the latter six nerves innervate the head and neck, as well as organs and tissues in the thoracic and abdominal cavities. They facilitate communication, expression, and autonomic control within the human body.
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
2.4K
Blood and Nerve Supply to the Bones
10.9K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
10.9K
Nociception
27.8K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.8K
Cranial Part of Parasympathetic Division
1.2K
The cranial part of the parasympathetic division plays a crucial role in regulating the visceral functions of the head and specific structures in the neck, thoracic, and abdominopelvic cavities. Preganglionic fibers of the parasympathetic division exit the brain through cranial nerves III (oculomotor), VII (facial), IX (glossopharyngeal), and X (vagus), delivering parasympathetic output to the respective visceral structures.
The vagus nerve (cranial nerve X) alone accounts for approximately 75...
The vagus nerve (cranial nerve X) alone accounts for approximately 75...
1.2K
Sympathetic Pathways: Sympathetic Chain Ganglia
2.4K
The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.
The postganglionic neurons of the sympathetic trunk...
The postganglionic neurons of the sympathetic trunk...
2.4K


