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由Gprasp2删除扰乱的母体行为调节后代的神经发育轨迹

Marta I Pereira^1,2, Mariana Laranjo^1,3,4, Marcos Gomes^1,3,4

¹CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.

Scientific reports

|May 30, 2024

概括

影响母亲行为的基因突变在自闭症谱系障碍 (ASD) 模型中破坏后代的发展. 在雌性小鼠中,Gprasp2基因被删除会损害母亲的照顾和幼的沟通,突出了性别特异性对神经发育的影响.

科学领域:

神经科学是一个神经科学.
遗传学遗传学是一个
发展生物学发展生物学

背景情况:

自闭症谱系障碍 (ASD) 呈现出性别特异性的差异.
母亲的行为对后代的神经发育至关重要,并可能受到遗传突变的影响.
了解基因型与环境之间的相互作用,特别是对母亲的影响,对于ASD研究至关重要.

研究的目的:

研究Gprasp2基因删除在雌性小鼠对孕产妇护理和后代发育的影响.
评估Gprasp2突变对社会行为,记忆和生理学的性别独立和性别特异性影响.

主要方法:

在野生型,异合体 (HET) 和淘汰 (KO) Gprasp2雌性小鼠及其后代的行为分析.
评估焦虑,记忆,社会行为和母亲的照顾.
分析幼的超声波发声和交叉养实验,以评估母体基因型的影响.

主要成果:

Gprasp2 KO雌性表现出社会和工作记忆的损害,以及对母亲护理的干扰.
在突变雌性中观察到生理和分子变化,包括乳腺结构和催产素受体表达.
Gprasp2 KO幼表现出减少的发声,受母体和幼基因型的影响;交叉培养部分拯救的幼发声缺陷.

结论:

Gprasp2突变影响社会和工作记忆,不论性别,但显著影响与后代护理和生理学相关的女性特异性行为.
在Gprasp2突变母体中,母亲的改变行为导致后代的发育障碍.
这项研究强调了考虑母体基因型和行为在理解ASD中基因型与环境相互作用方面的重要性.

关键词:

自闭症自闭症自闭症交叉培养是一种培养.在GPRASP2中,GPRASP2是GPRASP2中的一个.孕产妇的护理孕产妇的护理催产素受体的受体催产素受体性差异性差异性差异性差异性差异性差异性差异性超声波发声的声音.

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