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Yewei Yuan¹, Peng Sun², Hualin Xiao²

¹Department of Breast Surgery, Sichuan Provincial Maternity and Child Health Care Hospital, No. 290 West Second Street, Shayan Road, Chengdu, 610031, Sichuan, China.

Scientific reports

|May 30, 2024

概括

癌症病史和癌症治疗增加了患第二种原发性甲状腺癌 (SPTC) 的风险. 特定的前癌症和早期治疗显著提高了SPTC风险,尽管在匹配后的生存率与原发性甲状腺癌相似.

科学领域:

在瘤学瘤学.
流行病学流行病学

背景情况:

以前的癌症史和癌症治疗可能会增加患甲状腺癌 (TC) 的风险.
第二次原发性甲状腺癌 (SPTC) 的确切风险和特征需要进一步调查.

研究的目的:

评估SPTC的标准化发病率 (SIR) 与各种先前条件相关.
与初级TC相比,分析SPTC患者的临床病理特征和生存结果.

主要方法:

利用美国监测,流行病学和最终结果 (SEER) 计划 (1975-2019) 的数据.
计算SIRs,分析临床病理特征,并使用Kaplan-Meier方法评估生存率.
员工倾向性得分匹配 (PSM) 以平衡SPTC和初级TC组之间的共变量.

主要成果:

在患有先前瘤的患者中,TC的SIR显著高于一般人群 (0.94/10,000) (1.51/10,000).
急性淋巴细胞白血病,霍奇金淋巴瘤,唾液腺癌和癌与最高的SPTC风险有关.
35岁之前的放射治疗/化疗显著增加了TC发病率. SPTC患者的诊断是在年龄较大时进行的,并且有更高等级的瘤.
最初,SPTC显示出更糟糕的预后,但PSM使得SPTC和初级TC组之间的生存结果相当.

结论:

患有癌症史的患者患上SPTC的风险较高.
特定的先前恶性瘤和早期癌症治疗是SPTC的重要风险因素.
尽管初始呈现有差异,但SPTC的长期存活率在考虑混因素后与初级TC相当.

关键词:

风险风险风险风险风险在 SEER 数据库中,我们可以看到第二种主要的甲状腺癌.标准化的发病率比率.幸存的生存方式

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