在老年患有转移性乳腺癌的患者中,时间毒性的表征
Swarali Y Atre1, Pamela R Soulos2, Nicole M Kuderer3
1Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA. swarali.atre@gmail.com.
Breast cancer research and treatment
|May 30, 2024
概括
转移性乳腺癌 (MBC) 患者的时间毒性与并发症和放射治疗有关,而不是年龄本身. 了解这些因素有助于接受癌症治疗的老年人共同决策.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 时间毒性,定义为寻求医疗护理的时间,是患者的重大负担.
- 了解导致时间毒性的因素对于改善患者体验至关重要,特别是在转移性乳腺癌 (MBC) 的老年人中.
研究的目的:
- 调查MBC的老年患者诊断时的年龄和时间毒性之间的关联.
- 确定关键的护理组件,这些组件在这个人群中对时间毒性的贡献最为显著.
主要方法:
- 使用SEER-Medicare数据库进行的一项回顾性队列研究分析了2949名67岁及以上的MBC患者.
- 时间毒性是通过在治疗的第一年内遇到的几天来衡量,使用Poisson模型进行分析.
- 根据临床和社会人口统计学因素进行了调整,并根据治疗类型分层对接触日进行了分层.
主要成果:
- 虽然未经调整的分析表明,较长的年龄与更多的遭遇日相关,但在调整并发病症和治疗类型后,这种关联消失了.
- 患有超过三种并发症的患者经历的接触日数显著增加 (RR 1.36).
- 接受放射治疗增加了接触日 (RR 1.45),而骨修饰剂减少了这些日 (RR 0.75).
结论:
- 伴随性疾病和癌症治疗方法,特别是放射治疗,是老年MBC患者时间毒性的关键驱动因素.
- 评估个体的并发症概况和计划的治疗方法对于了解与年龄相关的对医疗保健利用的影响至关重要.
- 这种理解支持了共享决策,并有助于减轻MBC老年人的时间毒性.
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