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Updated: Jun 25, 2025

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C9orf72通过调节SREBP1的运输来控制肝脂代谢

Yachen Wu1,2, Wenzhong Zheng1, Guofeng Xu1

  • 1Brain Center, Department of Neurosurgery, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.

Cell death and differentiation
|May 30, 2024
PubMed
概括

C9orf72基因通过控制SEC16A蛋白水平来调节脂质稳态,这对于COPII囊泡形成至关重要. 它的缺失会损害醇调节元件结合转录因子 (SREBPs) 的运输,减少脂质生成,并为肥胖提供潜在的目标.

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