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Updated: Jun 25, 2025

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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Published on: April 20, 2021

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在生殖中心B细胞之间的亲和差距驱动MPER前体的选择

Rashmi Ray1, Torben Schiffner2,3,4,5, Xuesong Wang1

  • 1The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.

Nature immunology
|May 30, 2024
PubMed
概括

开发有效的人类免疫缺陷病毒 (HIV-1) 疫苗需要产生广泛中和抗体 (bnAbs). 这项研究探讨了针对生殖线的免疫原体如何引导MPER特异性前体向bnAbs,揭示了亲和力在生殖中心内的B细胞竞争中的关键作用.

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