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抗瘤原体耗尽的CD8+ T细胞是由TCR参与维持的

Xin Lan1,2, Tian Mi1, Shanta Alli1

  • 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Nature immunology
|May 30, 2024
PubMed
概括

最佳的T细胞受体 (TCR) 信号传递对于维持原始CD8+ T细胞 (Tpex) 的维持至关重要,这些细胞补充抗瘤免疫力. 不足的TCR参与加速了Tpex分化,阻碍了持续的抗癌反应.

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