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Updated: Jun 25, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
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在急性髓性白血病中准特定的PI3Kɣ-Akt信号模块,使用异构功能降解分子降解剂

Lois M Kelly1, Justine C Rutter2, Kevin H Lin2

  • 1INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France.

Nature cancer
|May 30, 2024
PubMed
概括

在急性髓性白血病 (AML) 中准PIK3CG/p110γ-PIK3R5/p101通路可以抑制癌细胞的生长. 一个新的PROTAC分子有效降解PIK3CG,提供了一个有前途的新AML治疗策略.

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