慢性子宫内膜炎和子宫内膜微生物群:对复发性植入失败患者的生殖成功的影响
Hong Zhang1, Heng Zou1, Chanyu Zhang1,2
1The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Annals of clinical microbiology and antimicrobials
|May 30, 2024
概括
复发性植入失败 (RIF) 的女性慢性子宫内膜炎 (CE) 与独特的子宫内膜细菌和改变的代谢途径有关. 这些微生物变化可能会对生殖结果和体外受精 (IVF) 成功产生负面影响.
科学领域:
- 生殖医学 生殖医学
- 微生物组研究 微生物组研究
- 遗传学 遗传学 是一个
背景情况:
- 慢性子宫内膜炎 (CE) 与不良的生殖结果有关.
- 子宫内膜微生物群在CE的复发性植入失败 (RIF) 中的作用尚不清楚.
研究的目的:
- 在RIF患有CE的患者中描述子宫内膜微生物群.
- 评估子宫内膜微生物群,CE和生殖结果之间的关联.
主要方法:
- 前性研究招募了具有和没有CE的RIF患者.
- 对子宫内膜和子宫样本的16S rRNA基因测序.
- 微生物群组成,多样性和代谢途径的分析;与生殖结果的相关性.
主要成果:
- 结核病患者表现出子宫内膜微生物多样性增加和细菌组成不同 (蛋白质细菌,阿米尼森塔尔,Chloroflexaceae).
- 特定的细菌种群和改变的代谢途径与CE和不良生殖结果有关.
- 在CE和非CE组之间观察到明显的微生物聚类.
结论:
- 患有CE的RIF患者具有独特的子宫内膜微生物群,与不良的生殖结果有关.
- 在CE中改变的微生物多样性和代谢途径可能会影响生育能力.
- 准子宫内膜微生物组可能是一个新的策略,以改善CE患者的试管婴儿结果.
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