产前血压轨迹和变异性与2岁儿童神经发育的关联
Luli Xu1, Jiayi Cheng1, Xiaohan Dong1
1Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
BMC medicine
|May 30, 2024
概括
孕期血压 (BP) 模式和变化影响孩子的神经发育. 特定的血压轨迹和高血压变异性与儿童的认知分数降低和发育迟缓有关.
科学领域:
- 产科和妇科 产科和妇科
- 儿科神经学 儿科神经学
- 心血管健康 心血管健康
背景情况:
- 孕期血压 (BP) 变化与不良分娩结果有关.
- 母亲血压模式对儿童神经发育的长期影响尚不清楚.
研究的目的:
- 为了研究母亲血压轨迹和怀孕期间的变化以及幼儿时代神经发育之间的关系.
- 为了确定与神经发育延迟相关的特定BP模式.
主要方法:
- 在武汉健康婴儿队列研究中利用了2797对母婴对的数据.
- 在2岁时使用贝利婴儿发育尺度 (BSID) 评估儿童的神经发育.
- 采用基于组的多轨迹建模用于BP模式和计算的BP变化指标 (CV,SD,ARV).
主要成果:
- 确定了五种不同的静缩和静缩血压轨迹 (例如",低升"",高稳定").
- 除了"低稳定"之外的孕产妇血压轨迹与较低的精神运动发育指数 (PDI) 得分有关.
- 高静脉血压变化 (DBP-SD,DBP-CV) 与较低的BSID得分和延迟精神运动神经发育风险增加相关.
结论:
- 孕妇的血压模式和怀孕期间访问的变化与儿童的神经发育结果有关.
- 医疗保健提供者应考虑怀孕期间母亲的血压动态作为延迟神经发育的潜在危险因素.
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