豆补充剂通过重新编程肝脏新陈代谢来缓解营养不良,这是在一个新的营养不良非人类灵长类动物模型中
Zhenzhen Xu1, William Kwame Amakye1, Zhengyu Ren2,3
1School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, China.
概括
使用体重对年龄z-score (WAZ) 的新方法识别了非人类灵长类动物 (U-NHPs) 的营养不良. 豆治疗通过恢复线粒体功能和脂质代谢来改善WAZ得分.
科学领域:
- 生物医学研究生物医学研究
- 代谢障碍 代谢障碍 代谢障碍
- 灵长类动物模型
背景情况:
- 目前针对营养不良的饮食疗法,由于研究模型不足,提供了暂时的恢复.
- 营养不良的机制性探索需要更相关的临床前模型.
研究的目的:
- 建立一个与人类相关的标准,用于识别非人类灵长类动物 (NHPs) 的营养不良.
- 调查营养不良引起的多器官病理背后的分子机制.
- 评估大豆补充剂在缓解营养不良方面的有效性.
主要方法:
- 开发了一个体重对年龄z-score (WAZ) 标准 (≤-1.83),用于识别营养不良的NHP (U-NHP),使用1636 Macaca fascicularis.
- 在U-NHP中表现出病理异常和肝脂代谢失调,重点关注线粒体功能.
- 评估大豆治疗对U-NHPs WAZ评分,线粒体功能和脂质代谢的影响.
主要成果:
- 鉴定了严重的肝脂代谢失调,主要是由于线粒体功能障碍 (线粒体数量减少,脂肪酸氧化受损,OXPHOS复合物中断),作为U-NHPs的一个关键特征.
- 豆补充剂导致U-NHP中WAZ得分增加.
- 在大豆治疗后观察到减弱的线粒体功能障碍和恢复的OXPHOS复杂水平.
结论:
- 建立了识别U-NHP的创新标准,并揭示了营养不良的新型分子机制.
- 豆补充剂有效地重新编程了线粒体功能,恢复了脂质代谢平衡,并减轻了NHP中的营养不良.
更多相关视频
11:36A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
Published on: April 28, 2016
9.3K
08:04Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
Published on: October 23, 2018
18.9K
相关概念视频
Overview of Protein Metabolism
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Regulation of Food Intake
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
