在中风癌症患者中右向左分流的患病率
Fabienne Steinauer1, Philipp Bücke1, Eric Buffle2,3
1Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
概括
在患有癌症的急性缺血性中风 (AIS) 患者中,右向左的分流 (RLS) 较少见. 这表明动脉源,而不是矛盾的栓塞,更可能是癌症相关中风的原因.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 在瘤学瘤学.
背景情况:
- 癌症患者面临急性缺血性中风 (AIS) 和静脉血栓栓塞的风险增加.
- 在与癌症相关的中风中,心脏右向左转换 (RLS) 的作用尚不清楚.
- RLS可能会成为悖论性栓塞的途径.
研究的目的:
- 在AIS患者中调查RLS存在与活跃癌症之间的关联.
- 确定RLS是否是癌症患者中风病因的重要因素.
主要方法:
- 从2015年1月到2020年12月连续发生AIS患者的回顾性分析.
- 通过食道横断性心声学 (TEE) 确定RLS状态.
- 多变量逻辑回归和治疗权重的逆概率用于评估RLS与癌症之间的关联.
主要成果:
- 在4.6%的AIS患者中诊断出活跃癌症.
- 与没有癌症 (36%) 相比,患有活跃癌症的AIS患者 (23%) 的RLS发病率较低.
- 没有RLS与活跃的癌症有关 (aOR 2.29).
结论:
- 在患有癌症的AIS患者中,RLS的诊断较少.
- 在与癌症有关的中风中,动脉源可能比矛盾的静脉栓塞更为普遍.
- 需要进一步的研究来探索治疗意义,包括专利卵巢孔 (PFO) 关闭.
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