预测明天:使用预测结果的预测器来定制帕金森症的症状治疗
Ronald B Postuma1, Daniel Weintraub2, Tanya Simuni3
1Department of Neurology, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Movement disorders clinical practice
|May 31, 2024
概括
这项研究为个性化的帕金森病 (PD) 治疗提供了专家建议,使用亚型和结果预测来指导症状治疗. 这些可适应的建议有助于临床医生根据个体患者的发展轨迹量身定制护理.
科学领域:
- 神经学 神经学
- 临床治疗学 临床治疗学
- 个性化医疗是个性化的医疗.
背景情况:
- 帕金森病 (PD) 研究在了解亚型和预测结果方面取得了进展.
- 然而,使用这些预测用于当前治疗决策的指导是有限的.
研究的目的:
- 制定基于专家意见的建议,以定制PD的症状治疗方法.
- 建议是基于风险预测和患者亚型.
主要方法:
- 运动障碍学会 (MDS) 关于PD亚型的特别工作组使用了修改后的Delphi方法.
- 专家小组成员提出并修订了关于在治疗选择中使用亚型/结果预测指标的建议.
- 在经过四次代后,通过了超过75%的支持率的建议.
主要成果:
- 19个建议得到了13位小组成员的支持.
- 关键主题包括将未来的认知障碍风险纳入治疗计划.
- 另一个重点是确定未来的症状集群,可以通过单一药物来管理.
结论:
- 这些建议为将未来结果纳入患者特异性PD治疗提供了一个框架.
- 这些是可适应的建议,而不是规范性的指导方针,需要个别定制.
- 这项工作是迈向发展,个性化风险预测引导的PD治疗的第一步.
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