铁负担和内分泌并发症在输血依赖的血病患者在马来西亚萨拉瓦克:一个回顾性研究
L C Chow1, B S Lee2, S O Tang3
1Sarawak General Hospital, Department of Medicine, Haematology Unit, Jalan Hospital, Kuching, Sarawak, Malaysia. connie_chow2002@hotmail.com.
The Medical journal of Malaysia
|May 31, 2024
概括
萨拉瓦克的输血依赖性血病 (TDT) 患者显示内分泌疾病的高患病率,与铁过载和输血持续时间密切相关. 早期检测和管理对于改善患者的治疗结果至关重要.
科学领域:
- 血液学 血液学 血液学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 沙拉西米亚是马来西亚的一个重大健康问题,输血依赖的沙拉西米亚 (TDT) 患者面临由定期输血引起的铁过载导致内分泌疾病的风险增加.
- 有效的铁过载监测对于预防TDT患者末端器官损伤至关重要.
研究的目的:
- 为了评估萨拉瓦克的TDT患者的铁负担.
- 为了确定Sarawak的TDT患者内分泌病变的患病率.
主要方法:
- 从2020年1月到2020年6月,在萨拉瓦克的六家政府医院进行了一项回顾性队列研究.
- 招募了89名10岁及以上的TDT患者.
主要成果:
- 该研究发现89名TDT患者中内分泌疾病的患病率为69.7%.
- 常见的内分泌异常包括身材矮小 (51.7%),阴道腺缺陷 (26.9%) 和晚期青春期 (25.8%).
- 在34.8%和66.6%的患者中,分别观察到高铁负担 (血清费里丁≥2500ng/ml或LIC≥7mg/g). 内分泌病变与年龄,输血开始时的年龄和输血持续时间有显著的关联.
结论:
- 在TDT患者中,内分泌病变的发展是时间依赖的,这突出了早期检测和及时铁化疗法的需要.
- 采用多学科方法和强有力的患者与医生的协作对于提高TDT患者的护理和改善疾病发病率和死亡率至关重要.
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