在口腔状细胞癌中,LncRNA EIF3J-DT促进化学抵抗
Seon Hyun Kim1, Hye Jung Kim1, Yeong Joo Kim2,3,4
1Periodontal Disease Signaling Network Research Center (MRC), School of Dentistry, Pusan National University, Yangsan, Korea.
Oral diseases
|May 31, 2024
概括
EIF3J-DT被确定为口腔状细胞癌 (OSCC) 诊断和预后的一个关键因素. 这种长长的非编码RNA通过影响亡,细胞循环和自来促进化学抵抗,为OSCC提供了潜在的治疗标.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 口腔状细胞癌 (OSCC) 在诊断和治疗方面存在挑战,特别是在化学抵抗方面.
- 确定新的诊断,预后和治疗目标对于改善患者的治疗结果至关重要.
研究的目的:
- 查口腔状细胞癌 (OSCC) 的诊断和预后候选人.
- 调查已识别的候选物质在OSCC细胞系的化学抵抗中的作用.
主要方法:
- 来自癌症基因组图谱 (TCGA) 数据库的OSCC患者长非编码RNA (lncRNA) 的差异表达概况.
- 在OSCC细胞系中使用MTT试验对Taxol耐药性的分析.
- 研究EIF3J-DT对细胞亡,细胞循环和自的调节作用,通过流细胞计和西斑在转染的OSCC细胞系中进行.
主要成果:
- EIF3J-DT被确定为OSCC诊断和预后的重要候选者.
- 在OSCC细胞系中,EIF3J-DT表达水平与Taxol耐药性相关.
- 沉默EIF3J-DT通过诱导细胞亡,细胞循环停止和抑制自而减少化学抵抗.
- 过度表达EIF3J-DT在OSCC细胞系中增强化学抵抗.
结论:
- EIF3J-DT通过调节细胞亡,细胞循环和自,在OSCC中诱导化学抵抗方面发挥着关键作用.
- EIF3J-DT代表了OSCC的潜在新型诊断和预后因素.
- 向EIF3J-DT可能为克服OSCC的化学抵抗提供了一个新的治疗策略.
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