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Updated: Jun 25, 2025

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阻塞性睡眠呼吸暂停和肌缩性侧面硬化症之间的因果关系:孟德尔的随机化研究

Rongrong Du1,2, Yahui Zhu1,3, Peng Chen3,4

  • 1Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.

Frontiers in aging neuroscience
|May 31, 2024
PubMed
概括

阻塞性睡眠呼吸暂停 (OSA) 可能会增加肌缩侧面硬化症 (ALS) 的风险. 这项研究发现了OSA与患ALS风险更高之间存在因果关系的潜在证据.

关键词:
门德尔的随机化骨髓缩侧面硬化症 (ALS) 是一种有关因果关系的因果关系遗传关联 遗传关联 遗传关联阻塞性睡眠呼吸暂停 (SOP) 的情况.

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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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