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在非酒精性脂肪肝中新型多草药配方的急性和次慢性毒性研究中,使用Wistar大鼠对非酒精性脂肪肝进行了研究

Anuragh Singh¹, K Ilango²

¹Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science & Technology, Kattankulathur - 603 203, Chengalpattu (Dt), Tamil Nadu, India.

Future science OA

|May 31, 2024

概括

这项研究评估了一种新的多草药片.

科学领域:

药理学和毒理学药理学和毒理学
自然产品研究自然产品研究

背景情况:

多草药配方在传统医学中越来越多地使用.
在人类使用之前,评估新型草药产品的安全性至关重要.

研究的目的:

为了确定新型多草药配方药片的急性和次慢性毒性.
在临床前环境中确定多草药片的安全性.

主要方法:

急性毒性测试遵循经合组织指南423.
亚慢性毒性测试 (90天) 遵循经合组织指南408.
在Wistar大鼠中进行了研究,对Wistar小鼠进行了口服药片的研究.

主要成果:

在急性毒性测试中,中位致命剂量 (LD50) 确定为2000 mg/kg.
在90天的研究中,与对照组相比,在所有测试剂量 (250,500,1000,2000毫克/公斤) 的血液学,生化学或组织病理学参数中没有发现显著差异.
没有观察到的不良影响水平 (NOAEL) 确定为2000 mg/kg.

结论:

这种新型多草药配方药片表现出良好的安全性.
在测试的最高剂量之前,没有发现任何不良反应,这表明毒性很低.
这些发现支持了这种多草药配方进一步开发和使用的潜力.

关键词:

诺亚尔·诺亚尔 (NOAEL) 是一个一个PHF平板电脑.剧烈毒性的急性毒性无酒精脂肪肝是一种非酒精脂肪肝.亚慢性毒性亚慢性毒性

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