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初级甲状腺功能低下症患者贫血的频率和类型:一项前性观察性研究
Syed Shahiq Ali1, Muhammad Noman Khan2, Fatima Zafar3
1Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.
Cureus
|May 31, 2024
概括
贫血在一次性甲状腺功能低下症中很常见,影响67%的患者. 正常细胞性贫血是最常见的类型,强调需要确定特定的贫血原因,以有效治疗低甲状腺症患者.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
背景情况:
- 初级甲状腺功能低下症是一种常见的内分泌疾病,其特点是甲状腺激素的生产不足.
- 贫血经常与甲状腺功能低下症同时发生,可能源于营养缺乏或慢性疾病.
- 确定贫血的原因对于低甲状腺患者的有效治疗至关重要.
研究的目的:
- 为了调查患有初级甲状腺功能低下症的个体中贫血的患病率和类型.
- 为了确定这个患者群体中正常细胞,微细胞和宏细胞贫血的频率.
主要方法:
- 一项前性,横截面的观察性研究与176名新诊断的原发性甲状腺功能低下症患者 (18-65岁) 进行.
- 收集的数据包括人口统计和完整血清 (CBC) 参数 (Hb,MCV) 以诊断贫血及其亚型.
- 在统计分析中使用了奇二次测试,显著水平为p < 0.05.
主要成果:
- 观察到贫血的高患病率,其中67%的患者受到影响.
- 正常细胞性贫血是最常见的类型 (38.64%),其次是微细胞性贫血 (19.32%) 和宏细胞性贫血 (9.25%).
- 贫血在女性 (74.29%) 与男性 (56.34%) 相比更为普遍,具有统计学意义 (p = 0.01).
结论:
- 这项研究证实了初级甲状腺功能低下症中贫血的高频率,而正常细胞贫血占主导地位.
- 了解特定类型的贫血至关重要,因为正常细胞贫血可能表明慢性疾病的贫血,可能对营养补充无反应.
- 微细胞和巨细胞贫血表明铁和维生素B12分别缺乏,需要向的替代疗法.
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